Department of Environment Science (2012 - Present)
Organic Chemistry
Chemistry, Khaje Nasir al-Din Tusi University of Technology, Tehran, Iran
Chemistry - Organic Chemistry
Chemistry, Shahid Beheshti University, Tehran, IRAN
pure chemistry
Chemistry, Chamran martyr of Ahwaz University, Ahwaz, IRAN
I was born in Ahwaz in 1963 Marriaged two Childs
Design, Synthesis, Molecular Docking, and Kinetic Study of 3-Amino-2, 4-Diarylbenzo [4, 5] Imidazo [1, 2-a] Pyrimidines as Novel, Potent Α-Glucosidase Inhibitor
Donor numbers (DNs) of binary mixtures of acetonitrile with methanol, ethanol, ethylene glycol, 1‐butanol, and tert‐butanol were calculated in the whole range of mole fractions based on 23Na‐NMR chemical shift of sodium perchlorate dissolved in solvent. Data showed positive deviation from hypothetical linear ideal behavior. Solvatochromic parameters including empirical polarity, dipolar/polarizability, hydrogen bond donor, and hydrogen bond acceptor of the solvent mixtures were spectrophotometrically measured in order to investigate the correlations among parameters. The trend of data showed the preferential solvation along with synergistic behavior in some of mixtures. Applying preferential solvation model confirmed the solvent‐so
In this project, a moderately efficient approach to multisubstituted N-(isoquinolin-1-yl)sulfonamide derivatives was illustrated, utilizing ortho-alkynylbenzaldoximes and zwitterionic ketenimine salts in a tandem reaction catalyzed by silver oxide. The oxophilicity of Ag2O, along with its nature as Lewis acid, pave the way for a smooth [3 + 2] cycloaddition between isoquinoline N-oxides and ketenimine species, which is a key step in this reaction. DFT calculation suggests that 1,3-dipolar cycloaddition of nitrone and ketenimine proceeds through a selective stepwise mechanism.
Cancer has emerged as the main cause of the highest rate of mortality in the world. Drugs used in cancer, although, show some beneficial effects on cancerous organs, demonstrate side effects on other normal tissues. On the other hand, anticancer peptides, being effective on target tissues, should be safe and less harmful on healthy organs, since peptides have several advantages, i.e., high activity, specificity, affinity, being less immunogenic and not accumulate in the body. In the present work, analogues of Longicalcynin A, a naturally occurring anticancer cyclopeptide, were synthesized and evaluated their cytotoxicity in order to gain information from structure-activity relationships of the such cyclopeptides which may lead to find novel
An efficient and diversity-oriented access to functionalized pyrrolidin-2-ones through an Ugi reaction of readily available starting materials with a subsequent transformation is described. A two-step reaction sequence of a four-component Ugi reaction and an intramolecular radical-cyclization reaction leads to the chemo- and regioselective formation of a single product with high atom economy and good to high yields. The radicalization of the pseudopeptides generated from the first step by a cavitational mechanism produces the key intermediate for the ultrasound-activated formation of γ-lactams as the final products by β-Michael addition. Among the advantages of this approach are its use of cavitation bubble implosion as an exclusive path
Europe PMC is an archive of life sciences journal literature.
BackgroundIncreasing bacterial resistance to quinolones is concerning. Hence, the development of novel quinolones by chemical modifications to overcome quinolone resistance is an attractive perspective in this context.ObjectiveIn this study, it is aimed to design and synthesize a novel series of functionalized fluoroquinolones using ciprofloxacin and sarafloxacin cores by hybridization of quinazolinone derivatives. This objective was tested by a comprehensive set of in vitro antibacterial assays in addition to SAR (structure–activity relationship) characterisation studies.MethodsA nucleophilic reaction of ciprofloxacin and sarafloxacin with 2-(chloromethyl) quinazolin-4 (3H)-one in the presence of NaHCO 3 in dimethylformamide (DMF) was pe
Abstract A series of quinazolin-4 (3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC 50= 17.7 μ M) which was comparable with sorafenib (IC 50= 17.3 μ M). There was also a significant reduction in the number of HUVEC cells, when they were exposed to compound 9y (IC 50= 6.1 μ M). To test the potential of compounds in inducing apoptosis, Annexin V-FITC/propidium iodide double staining assay was used. After the treatment of HUVEC cells with 9f, they underwent apoptotic effects. A substantial effort was dedicated to gathering comprehensive data across CAM assay. These data showed that 9f moderately inhibits the
Small peptides are valuable peptides due to their extended biological activities. Their activities could be categorized according to their low antigenicity, osmotic pressure, and also because of their astonishing bioactivities. For example, the aggression of Phe-Phe fibers via self-assembly and intermolecular hydrogen bonding is the main reason for the formation of Alzheimer’s β-amyloid fibrils. Hydrogen bonding is the main intramolecular interaction in peptides, while the presence of aromatic ring leads to the π-π stacking and affects the self-assembly and aggression. Thus, insertion of an unusual amino acid into peptide sequence facilitates the formation of intramolecular bonds, lipophilicity and its conformation. To design new small
A simple and straightforward approach has been developed for the synthesis of functionalized fused oxazepine and diazepine analogues containing coumarin backbone. The approach was done through three‐component reaction of 4‐chloro‐3‐formylcoumarin, triphenyl‐λ5‐phosphanylidene derivatives and 2‐aminophenol or o‐phenylenediamine derivatives in the presence of cesium carbonate at room temperature. Carrying out the same reaction without base led to 4‐aminoarylcoumarins. Mild reaction conditions and synthesis of fused functionalized heterocyclic backbones are advantages of this approach.
A simple, green protocol has been accomplished for the synthesis of amidoesters 5 a‐k in choline chloride/urea (1:2) through multicomponent reaction of 3‐formyl chromone, Meldrum's acid, isocyanides and primary alcohols via a domino reaction. Carrying out the reaction using trifluoroethanol led to succinimide derivatives 6 a‐d. Easy work‐up, selectivity, and good to excellent yields are the advantages of this protocol.
Article: Enhancement of calcium/vitamin D supplement efficacy by administering concomitantly three key nutrients essential to bone collagen matrix for the treatment of osteopenia in middle-aged women: a one-year follow-up
Synthesis of functionalized 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one from a cascade reaction between 3-formylchromone, malononitrile, diammonium hydrogen phosphate, and aromatic aldehydes in aqueous media is described.
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